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Assessment of tumor microcirculation with dynamic contrast-enhanced MRI in patients with esophageal cancer: Initial experience

✍ Scribed by Katja Oberholzer; Andreas Pohlmann; Wolfgang Schreiber; Peter Mildenberger; Peter Kunz; Heinz Schmidberger; Theodor Junginger; Cristoph Düber

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
235 KB
Volume
27
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To investigate the feasibility and impact of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) on tumor characterization and response to radiochemotherapy (RCT) in patients with esophageal cancer.

Materials and Methods

A total of 48 patients underwent DCE‐MRI to assess tumor microcirculation based on a two‐compartment model function. Effects of RCT on kinetic parameters were studied in 12 patients with squamous cell carcinoma.

Results

Tumor microcirculation differs with respect to histological subtype: squamous cell carcinomas showed lower values of amplitude A (leakage space, P = 0.015) and higher contrast agent exchange rates (k~21~, P = 0.225) compared with adenocarcinomas. RCT led to a significant decrease of the contrast agent exchange rate (P = 0.005), while amplitude A increased moderately after therapy (P = 0.136).

Conclusion

DCE‐MRI is feasible in patients with esophageal cancer, reveals therapeutic effects, and may thus be useful in therapy management and monitoring. J. Magn. Reson. Imaging 2008;27:1296–1301. © 2008 Wiley‐Liss, Inc.

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