Assessment of role of rosmarinic acid in preventing oxidative process of low density lipoproteins

✍ Scribed by Tache, Andreia; Radu, Gabriel-Lucian; Litescu, Simona-Carmen

• Book ID: 118129692
• Publisher: Versita
• Year: 2012
• Tongue: English
• Weight: 280 KB
• Volume: 66
• Category: Article
• ISSN: 0366-6352
• DOI: 10.2478/s11696-012-0233-4

✦ Synopsis

Abstract

This study aimed to assess the antioxidant compound effects on oxidisable substrates, using an effective bio-mimetic system based on human low density lipoproteins (LDL). Thermally generated radicals induce LDL oxidative changes to be identified and quantified. The bio-mimetic system thus developed responded linearly to radicals’ concentration over a range of 10−6-10−5 mol L−1. Cu2+ accentuates lipoperoxidation but, when rosmarinic acid was present, Cu2+ produced an unexpected effect, i.e. increased antioxidant efficiency against lipoperoxidation. Rosmarinic acid inhibits production of lipoperoxides by up to 30 % in the absence of Cu2+ and up to 70 % in its presence when the rosmarinic acid-to-Cu molar ratio is 1: 1.