𝔖 Bobbio Scriptorium
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Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein

✍ Scribed by Kavita Singh; Ramesh Chander; Narinder K. Kapoor

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
96 KB
Volume
11
Category
Article
ISSN
0951-418X

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✦ Synopsis

The oxidation of low density lipoprotein (LDL) induced by Cu +2 caused marked oxidative changes in the lipid and protein constituents of this lipoprotein in vitro. Guggulsterone prevented the generation of lipid peroxides measured as thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes. This compound protected LDL against depletion of lipid constituents such as cholesterol, cholesterol esters, triglyceride and phospholipids as well as inhibiting the conversion of cholesterol into oxygenated cholesterols. Oxidized LDL containing less apoprotein B with a high protein carbonyl value, was more electronegative, as evidenced by the increase in relative electrophoretic mobility (REM) on agarose gel. Guggulsterone significantly protected LDL apoprotein as measured by reversal of REM after oxidation. The protective action of guggulsterone may be due to its free radical scavenging property as this compound significantly inhibited the generation of hydroxyl radicals in a nonenzymic system.

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