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Assessment of mitochondrial function in vivo: Validation of a breath test using 14C-keto-isocaproic acid in alcoholic and cirrhotic rats


Book ID
123389043
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
74 KB
Volume
7
Category
Article
ISSN
0168-8278

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Assessment of mitochondrial function in
✍ Patrice A. Michaletz; Ludèk Cap; Elliot Alpert; Bernhard H. Lauterburg 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 450 KB

A breath test to assess hepatic mitochondrial function in vivo was evaluated in rats. Following the i.p. administration of [ l-'4C]-a-ketoisocaproic acid, 14C0, exhalation reached a peak within 10 to 20 min and then declined exponentially, with a half-life of 14.3 min. Control animals exhaled 38.6%