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Assessment of keto isocaproic acid decarboxylation by breath analysis. An in vivo test of hepatic mitochondrial function

✍ Scribed by Breen, K.; Cap, L.; Lauterburg, B.H.


Book ID
122609118
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
62 KB
Volume
9
Category
Article
ISSN
0168-8278

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Assessment of mitochondrial function in
✍ Patrice A. Michaletz; Ludèk Cap; Elliot Alpert; Bernhard H. Lauterburg 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 450 KB

A breath test to assess hepatic mitochondrial function in vivo was evaluated in rats. Following the i.p. administration of [ l-'4C]-a-ketoisocaproic acid, 14C0, exhalation reached a peak within 10 to 20 min and then declined exponentially, with a half-life of 14.3 min. Control animals exhaled 38.6%