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Assessment of comparative modeling in CASP2

✍ Scribed by Martin, Andrew C. R.; MacArthur, Malcolm W.; Thornton, Janet M.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 285 KB
Volume: 29
Category: Article
ISSN: 0887-3585
DOI: 10.1002/(sici)1097-0134(1997)1+<14::aid-prot4>3.0.co;2-o

No coin nor oath required. For personal study only.

✦ Synopsis

An assessment is presented for all submissions to the comparative modeling challenge in the 1996 Critical Assessment of Structure Prediction (CASP2). Of the original 12 target structures, 9 were solved prior to the meeting: 8 by X-ray crystallography and 1 by NMR spectroscopy. These targets varied over a large range of difficulty, as assessed by the percentage sequence identity with the principal parent structure, which ranged from 20% up to 85%. The overall quality of the models reflected the similarity of the principal parent. As expected, when the sequence alignment was correct, the core was accurately modeled, with the largest deviations occurring in the loops.

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