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Assessment of cell-mediated immunity to malignant mesothelioma by microcytotoxicity tests

✍ Scribed by M. J. Embleton; R. W. Baldwin; J. C. Wagner; M. M. F. Wagner; P. D. Oldham; J. S. P. Jones; G. Sheers

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
462 KB
Volume
17
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Cell cultures were established from pleural effusions of patients with pleural mesothelioma, and peripheral mononuclear effector cells were tested for cytotoxicity against these cells by means of a microcytotoxicity assay. Effector cells were obtained from normal healthy donors and from persons exposed occupationally to asbestos, including apparently healthy persons, patients with benign pleural conditions and patients with malignant mesothelioma. The overall incidence of cytotoxicity was low, and there was no evidence of increased cytotoxicity in mesothelioma patients or other asbestos‐exposed donors. It is concluded that little or no tumour‐directed cellmediated immunity is detectable against malignant mesothelioma by microcytotoxicity methods.

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