Cell-mediated immunity to human oral leukoplakia demonstrated by the leukocyte migration test

✍ Scribed by Bjarne Roed-Petersen; Jytte Roed-Petersen; Gunnar Bendixen

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: French
• Weight: 407 KB
• Volume: 12
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910120107

✦ Synopsis

Abstract

Tissue extracts from 11 oral leukoplakias and from normal oral mucosa of the same patients were tested in the LMT against autologous leukocytes. Five patients showed inhibition of the migration with leukoplakial tissue and one showed inhibition with normal mucosa. The migration of leukocytes from matched controls was not influenced by the tissue extracts, which accordingly had no non‐specific toxicity. It is concluded that oral leukoplakia is associated with a state of tissue‐specific, cellular hypersensitivity against antigenic components of the leukoplakial tissue.