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Assembling a Gene Regulatory Network for Specification of the B Cell Fate

✍ Scribed by Kay L. Medina; Jagan M.R. Pongubala; Karen L. Reddy; David W. Lancki; Rodney DeKoter; Matthias Kieslinger; Rudolf Grosschedl; Harinder Singh

Book ID
116403722
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
470 KB
Volume
7
Category
Article
ISSN
1534-5807

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Considerable progress has been achieved in the identification and analysis of regulatory molecules that orchestrate B and T cell fate determination. IL-7 and Notch signaling appear to represent analogous pathways that direct B and T cell fates, respectively. For the B lineage, it is possible to asse