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Assays for the analysis of P-glycoprotein in acute myeloid leukemia and CD34 subsets of AML blasts

✍ Scribed by Sonneveld, P; Wiemer, E


Book ID
110053530
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
259 KB
Volume
11
Category
Article
ISSN
0887-6924

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A bioassay was developed to assess P-glycoprotein (P-gp) function of peripheral blood natural killer (NK) cells and AML blasts during zosuquidar infusion. Cells were incubated with the fluorescent dye DiOC(2)(3) in the presence and absence of zosuquidar, and dye accumulation measured by flow cytomet