Assay of underivatized biphenyl metabolites by high-pressure liquid chromatography
β Scribed by M. Danny Burke; Russell A. Prough
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 479 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0003-2697
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π SIMILAR VOLUMES
which agrees satisfactorily with the sum of 107.0% found separately. The presence of a metal-I complex of this type is indicated whenever the residue resulting from the evaporation of the chloroform fraction does not completely dissolve in the alcohol solvent used for the determination of the cortic
## Abstract A reversedβphase HPLC assay method was developed to determine levels of the drugs trimethoprim, sulfamethoxazole and the N~4~βacetyl metabolite of the latter in human blood plasma and urine. The organic substances are extracted with ethyl acetate by a single extraction at pH 6.8. The me