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Assay methods for cyclosporine monitoring following liver transplantation

✍ Scribed by Mary C. Haven; Linda M. Sobeski; Robert A. Earl; Rodney S. Markin

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
674 KB
Volume
4
Category
Article
ISSN
0887-8013

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✦ Synopsis

This article reviews therapeutic drug monitoring for cyclosporine in liver transplantation.

Brief descriptions of various immunoassay methods include sample matrix selection, assay reagents, and metabolite cross-reactivity information. Multiple comparisons of the various methods are outlined. Examples of t h e method-dependent relationship between clinical events and changes in cyclosporine concentration are presented. Other potential predictors of liver allograft function are listed.

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Abbreviations: AUC 0 -6 , area under the curve for the first six hours post-dose; AUC 0 -12 , area under the curve for the first twelve hours post-dose; C 0, trough blood concentration; C 2, blood concentration at 2 hours after dose; C 4 , blood concentration at 4 hours after dose; C 6 , blood conce