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Aspirin Therapy for Colorectal Cancer With PIK3CA Mutation: Simply Complex!

✍ Scribed by Fuchs, C. S.; Ogino, S.

Book ID: 121351001
Publisher: American Society of Clinical Oncology
Year: 2013
Tongue: English
Weight: 933 KB
Volume: 31
Category: Article
ISSN: 0732-183X
DOI: 10.1200/JCO.2013.52.0080

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## Abstract The PI3K‐AKT pathway is activated in a variety of human cancers, resulting in disturbance of cell growth, proliferation and survival. Among the factors affecting the pathway, the __K‐Ras__ mutation and __PIK3CA__ mutation are the most common oncogenic alterations in colorectal cancer. W