Aspects of matrix effects in applications of liquid chromatography–mass spectrometry to forensic and clinical toxicology—a review
✍ Scribed by Peters, Frank T.; Remane, Daniela
- Book ID
- 111888536
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 330 KB
- Volume
- 403
- Category
- Article
- ISSN
- 1618-2650
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## Abstract Liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) technology is emerging as a complementary method to traditional methodology used for clinical applications. Enhanced specificity and high‐throughput capabilities are providing significant benefits to clinical diagnos
Matrix effects of different biological samples, including phosphate-buffered saline-bovine serum albumin (PBS-BSA), gelded horse serum, mouse serum, and mouse brain, were investigated for the determination of 17a-and b-estradiol using derivatization with dansyl chloride prior to LC-MS/MS. Matrix eff