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Aspects of adrenal function in neonatally estrogenized male mice

✍ Scribed by Simmons, J. Emmett ;DiClementi, David ;Maxted, George

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
307 KB
Volume
186
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Neonatal injection (day 5) of male CF1 mice with 50 ΞΌg of estradiol undecylate resulted in decreased body and testes weight and adrenal hypertrophy when these animals were examined at 95 days of age. The adrenal hypertrophy was associated with an increase in adrenal total cholesterol and plasma corticosterone after maximal ACTH stimulation. Orchiectomy of estradiol‐injected or oil‐injected control males did not significantly modify their response to ACTH stimulation. It is concluded that neonatal estrogenization of male mice causes, in addition to previously reported defects in subsequent reproductive function, long‐lasting changes in adrenal function.

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