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Origin of permanently altered epithelial cells of the vagina in neonatally estrogen-treated mice

✍ Scribed by Mori, Takao ;Iguchi, Taisen ;Takasugi, Noboru

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
596 KB
Volume
225
Category
Article
ISSN
0022-104X

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✦ Synopsis

In adult mice, neonatal injections of estrogen induce persistent, estrogen-independent cornification of the vaginal epithelium. Since the occurrence of nodules composed of affected epithelial cells (B cells

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## Abstract In untreated and neonatally‐estrogenized (E) Balb/c mice the numbers of hemidesmosomes per basal cell cross section (HD/bccs) gradually increases from 0.07 HD/bccs on day 1 to about 2 to 3 HD/bccs on day 4 __postpartum.__ In untreated mice the incidence of HD's increases and plateaus at