𝔖 Bobbio Scriptorium
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Aspecific and specific intermolecular interactions in aqueous media

✍ Scribed by C. J. van Oss

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
1008 KB
Volume
3
Category
Article
ISSN
0952-3499

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✦ Synopsis

Abstract

Aspecific as well as specific interactions involve the same noncovalent forces, consisting of Lifshitz‐van der Waals, Lewis acid/base, electrostatic, and thermal or Brownian movement interactions. In vivo, aspecific interactions between, e.g., cells and/or biopolymers usually are repulsive, while specific interactions are always attractive. The differences between the two classes of interactions can be shown to lie in the fact that aspecifically interacting bodies are large, while specifically interacting sites are small, or have a small radius of curvature, and in the fact that aspecifically interacting surfaces are homogeneous, whereas specific sites have a heterogeneous composition.

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Kinetics and Energetics of Specific Inte
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Taking into account the energy vs. distance functions of the aspecific (macroscopic) repulsion that usually prevails between antigen (Ag) and antibody (Ab) molecules in polar media, as well as the specific (microscopic) attraction between epitope and paratope of Ag and Ab, it proved possible to dete

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## Abstract Among the three different non‐covalent forces acting in aqueous media, i.e. Lifshitz–van der Waals (LW), Lewis acid–base (AB) and electrical double layer (EL) forces, the AB forces or electron–acceptor/electron–donor interactions are quantitatively by far the predominant ones. A subset