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Ascorbic acid metabolism and glycolysis in the polymorphonuclear leucocyte of the guinea pig

✍ Scribed by C. George Elliott; M. Doreen Smith

Publisher
John Wiley and Sons
Year
1966
Tongue
English
Weight
563 KB
Volume
67
Category
Article
ISSN
0021-9541

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✦ Synopsis

Exudate leucocytes lost approximately 30% of their original intracellular ascorbic acid content during two hour incubation in glucose medium. The same loss was observed for cells containing initially both high and low levels of ascorbic acid. High concentrations of ascorbic acid i n the incubation medium depressed lactic acid production and increased oxygen uptake by the cells. Iodoacetate and fluoride at low concentrations decreased ascorbic acid loss from cells during incubation; at high concentrations they increased loss. Ascorbic acid uptake from the medium was inhibited by iodoacetate but stimulated by fluoride.

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