The Interference of Aroclor 1254 with Progesterone Metabolism in Guinea Pig Adrenal and Testes Microsomes

✍ Scribed by Goldman, Daphne ;Yawetz, Aminadav

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 765 KB
• Volume: 5
• Category: Article
• ISSN: 0887-2082
• DOI: 10.1002/jbt.2570050204

✦ Synopsis

Ms. Goldman has submitted this work in partial fulfillment of the requirements of Tel Aviv University for a Ph.D. degree in zoology.

as when it was present in the incubation mixtures containing microsomes of untreated animals. The results of this study indicate a difference in the response of steroidogenic tissues to Aroclor 1254. In adrenal microsomes Aroclor 1254 may have modulated the steroidogenic activities at a posttranscriptional level, possibly by interfering with membrane regulation of these metabolic activities. At the same time, the results obtained do not exclude the possibility that Aroclor 1254 alters the composition of cytochrome P-450 isozymes present in adrenal tissue.