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Ascorbate regulation of collagen biosynthesis in Ehlers-Danlos syndrome, type VI

✍ Scribed by Philip P. Dembure; Anita R. Janko; Jean H. Priest; Louis J. Elsas


Book ID
118949445
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
675 KB
Volume
36
Category
Article
ISSN
1532-8600

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Collagen metabolism was studied in fibroblasts grown from a skin biopsy specimen of a patient who presented the striking clinical features of Ehlers-Danlos syndrome and, in particular, hyperextensibility of the skin, hypermobility of the joints, and kyphoscoliosis. A reduction in lysine hydroxylatio