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Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure–Activity Relationships, and Docking Studies (Part 1)

✍ Scribed by Roberto Di Santo; Roberta Costi; Marino Artico; Gaetano Miele; Antonio Lavecchia; Ettore Novellino; Alberto Bergamini; Reynel Cancio; Giovanni Maga


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
305 KB
Volume
1
Category
Article
ISSN
1860-7179

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Arylthiopyrrole (AThP) Derivatives as No
✍ Antonio Lavecchia; Roberta Costi; Marino Artico; Gaetano Miele; Ettore Novellino 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 381 KB

## Abstract Arylthio isopropyl pyridinylmethylpyrrolemethanols (AThPs) have been recently reported as a new class of human immunodeficiency virus type 1 (HIV‐1) reverse transcriptase (RT) inhibitors acting at the non‐nucleoside binding site (NNBS) of this enzyme. Docking experiments of the potent i