Downregulation of aryl hydrocarbon recep
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John J. Reiners Jr.; Carol L. Jones; Nancy Hong; Russell E. Clift; Cornelius Elf
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Article
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1997
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John Wiley and Sons
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English
โ 161 KB
The immortalized human epithelial cell line MCF10A has the phenotypic characteristics of normal breast cells. Exposure of MCF10A cultures to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) stimulated the transcriptional activation of cytochrome P450 1A1 (CYP1A1), and CYP1B1, and NAD(P)H:quinone oxidoredu