Aryl-Fused Nitrogen Heterocycles by a Tandem Reduction−Michael Addition Reaction
✍ Scribed by Bunce, Richard A.; Herron, Derrick M.; Ackerman, Matthew L.
- Book ID
- 119979001
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 61 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract A tandem S~N~2‐Michael addition reaction has been developed for the synthesis of __cis__‐ and __trans__‐fused nitrogen and sulfur heterocycles from the __cis__ and __trans__ isomers of ethyl (±)‐(2__E__)‐3‐[2‐(iodomethyl)cyclo‐hexyl]‐2‐propenoate. Octahydro‐1__H__‐isoindole‐1‐acetic aci
## Abstract magnified image Efficient syntheses of dibenz[__b,f__][1,4]oxazepin‐11(10__H__)‐one, 5,10‐dihydro‐11__H__‐dibenzo[__b,e__][1,4]‐diazepin‐11‐one and 5,11‐dihydro‐6__H__‐dibenz[__b,e__]azepin‐6‐one are described using a tandem reductionlactamization sequence. Precursors for these ring sy