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Aryl-Fused Nitrogen Heterocycles by a Tandem Reduction−Michael Addition Reaction

✍ Scribed by Bunce, Richard A.; Herron, Derrick M.; Ackerman, Matthew L.


Book ID
119979001
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
61 KB
Volume
65
Category
Article
ISSN
0022-3263

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## Abstract A tandem S~N~2‐Michael addition reaction has been developed for the synthesis of __cis__‐ and __trans__‐fused nitrogen and sulfur heterocycles from the __cis__ and __trans__ isomers of ethyl (±)‐(2__E__)‐3‐[2‐(iodomethyl)cyclo‐hexyl]‐2‐propenoate. Octahydro‐1__H__‐isoindole‐1‐acetic aci

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## Abstract magnified image Efficient syntheses of dibenz[__b,f__][1,4]oxazepin‐11(10__H__)‐one, 5,10‐dihydro‐11__H__‐dibenzo[__b,e__][1,4]‐diazepin‐11‐one and 5,11‐dihydro‐6__H__‐dibenz[__b,e__]azepin‐6‐one are described using a tandem reductionlactamization sequence. Precursors for these ring sy