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Aryl Bromides as Inexpensive Starting Materials in the Catalytic Enantioselective Arylation of Aryl Aldehydes: The Additive TMEDA Enhances the Enantioselectivity

โœ Scribed by Yang, Yong-Xin; Liu, Yue; Zhang, Lei; Jia, Yan-E; Wang, Pei; Zhuo, Fang-Fang; An, Xian-Tao; Da, Chao-Shan


Book ID
126706187
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
398 KB
Volume
79
Category
Article
ISSN
0022-3263

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Optically active set-alcohols in 90% enantiomeric excess were obtained from the enantioselective addition of dialkyl zincs to aryl aldehydes in the presence of a catalytic amount of dilithium salt of (2S, 52)-2, 5diisopropylpiperazine. Chiral piperazine (cyclic diamine) has rarely been utilized as c