Artificial oligonucleotides consisting of an analog of nucleoside antibiotics, carbocyclic oxetanocins

✍ Scribed by Nobuya Katagiri; Yoshihiro Morishita; Iichiro Oosawa; Masahiko Yamaguchi

• Book ID: 104262192
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 285 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)01410-0

✦ Synopsis

Modified oligonucleotides, hexadecamers, containing carbocyclic analogues of oxetanocin A and T, have been synthesized from the corresponding chiral carbocyclic nucleosides. The oligonucleotide derived from carbocyclic oxetanocin A forms a stable triple-helix with uridine oligoribonucleotide even under physiological conditions.