Artificial model for cystathionine β-synthase: efficient β-replacement reaction with thiols employing a novel pyridoxal model compound having an imidazole function

Artificial model for cystathionine β-syn

Artificial model for cystathionine β-synthase: construction of a catalytic cycle with a pyridoxal model compound having an ionophore function

✍ Kazuyuki Miyashita; Hidenobu Murafuji; Hiroshi Iwaki; Eito Yoshioka; Takeshi Ima 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 189 KB

Catalytic transformation of serine-O-carbonate to S-aryl cysteine derivatives was successfully achieved in the presence of Li þ by the use of a pyridoxal model compound having an ionophore function, which is the first example mimicking cystathionine b-synthase, artificially.