Arthritis in patients with psoriasis is associated with an immunoglobulin gene polymorphism
β Scribed by L. I. Sakkas; A. G. Demaine; G. S. Panayi; K. I. Welsh
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 281 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To investigate the association between potential environmental exposures and the development of psoriatic arthritis (PsA) in patients with psoriasis. ## Methods In this caseβcontrol study, the cases were patients with recentβonset PsA. The controls were psoriasis patient
CYP17 encodes the enzyme cytochrome P-450c17β£, which mediates both 17β£-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog