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Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells

โœ Scribed by Hui-Jun Zhou; Wei-Qin Wang; Guo-Dong Wu; Jun Lee; Ao Li


Book ID
118504409
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
871 KB
Volume
47
Category
Article
ISSN
1537-1891

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## Abstract In oxygenated cells, hypoxiaโ€inducible factorโ€1 (HIFโ€1) ฮฑ subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippelโ€“Lindau tumor suppressor E3 ligase complex using 2โ€oxoglutarate as a substrate. We examined the effect of 2โ€oxoglutarate on the production