Arterial shear stress induces synthesis and nuclear localization of c-fos in cultured human endothelial cells
β Scribed by V. Ranjan; S.L. Diamond
- Book ID
- 119154637
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 149 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0268-9499
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The c-fos protein belongs to a family of transcriptional cofactors that can complex with proteins of the Jun family and activate mRNA transcription from gene promoters containing an activator protein 1 (AP-1) binding element. The shear stress inducibility of the c-fos protein was studied in human an
Intracellular reactive oxygen species (ROS) may participate in cellular responses to various stimuli including hemodynamic forces and act as signal transduction messengers. Human umbilical vein endothelial cells (ECs) were subjected to laminar shear flow with shear stress of 15, 25, or 40 dynes/cm 2