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Arsenic trioxide induces procoagulant activity through phosphatidylserine exposure and microparticle generation in endothelial cells

✍ Scribed by Jin Zhou; Huibo Li; Yueyue Fu; Jialan Shi; Jinxiao Hou; Yingmei Zhang; Xiuhua Liu; Peng Song

Book ID: 116914641
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 765 KB
Volume: 127
Category: Article
ISSN: 0049-3848
DOI: 10.1016/j.thromres.2011.01.003

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## Abstract The observation that genistein may behave as a pro‐oxidant agent lead us to examine the capacity of this isoflavone to modulate the toxicity of the oxidation‐sensitive anti‐leukemic agent arsenic trioxide (ATO), and for comparison other anti‐tumor drugs. Co‐treatment with genistein incr