New cytotoxic agents are urgently needed for the treatment of advanced ovarian cancer because of the poor long-term response of this disease to conventional chemotherapy. Curcumin, obtained from the rhizome of Curcuma longa, has potent anticancer activity; however, the mechanism of curcumin-induced
โฆ LIBER โฆ
Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation
โ Scribed by Rajdeep Chowdhury; Suchandra Chowdhury; Paromita Roychoudhury; Chitra Mandal; Keya Chaudhuri
- Book ID
- 106349754
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 766 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1360-8185
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The mechanism of the induction of apoptosis by arsenic trioxide (As 2 O 3 ), which was demonstrated recently to be an effective inducer of apoptosis in patients with leukemia, was examined in detail in human leukemia U937 cells. Upon treatment of U937 cells with 50 M of As 2 O 3 , complete inactivat