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Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RAR Protein in Acute Promyelocytic Leukemia Cells

✍ Scribed by Shao, W.; Fanelli, M.; Ferrara, F. F.; Riccioni, R.; Rosenauer, A.; Davison, K.; Lamph, W. W.; Waxman, S.; Pelicci, P. G.; Lo Coco, F.; Avvisati, G.; Testy, U.; Peschle, C.; Gambacorti-Passerini, C.; Nervi, C.; Miller, W. H.


Book ID
127121578
Publisher
Oxford University Press
Year
1998
Tongue
English
Weight
361 KB
Volume
90
Category
Article
ISSN
0027-8874

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## Abstract Arsenic trioxide (ATO) induces differentiation and apoptosis in acute promyelocytic leukemia (APL). Several reports indicate that in APL cells apoptosis occurs mainly by a mechanism that involves the inhibition of glutathione peroxidase, one of the enzymes that regulates mitochondrial l