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Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells

✍ Scribed by Lunghi, P; Tabilio, A; Lo-Coco, F; Pelicci, P; Bonati, A


Book ID
110056108
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
400 KB
Volume
19
Category
Article
ISSN
0887-6924

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## Abstract Arsenic trioxide (ATO) induces differentiation and apoptosis in acute promyelocytic leukemia (APL). Several reports indicate that in APL cells apoptosis occurs mainly by a mechanism that involves the inhibition of glutathione peroxidase, one of the enzymes that regulates mitochondrial l