## ABSTRACT Arsenic (As) is a toxic metalloid element that is present in air, water and soil. Inorganic arsenic tends to be more toxic than organic arsenic. Examples of methylated organic arsenicals include monomethylarsonic acid [MMA(V)] and dimethylarsinic acid [DMA(V)]. Reactive oxygen species (
Arsenic toxicity in humans: Research problems and prospects
β Scribed by David J. Thomas
- Publisher
- Springer Netherlands
- Year
- 1994
- Tongue
- English
- Weight
- 497 KB
- Volume
- 16-16
- Category
- Article
- ISSN
- 1573-2983
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Most mammals metabolize inorganic arsenic to methylarsonic acid (MMA) and dimethylarsinic acid (DMA) by stepwise transfer of methyl groups from S-adenosylmethionine to arsenic in its trivalent oxidation state. The methylated metabolites are less reactive with tissue components, less toxic, and more