𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Resveratrol bioavailability and toxicity in humans

✍ Scribed by Charles-Henry Cottart; Valérie Nivet-Antoine; Christelle Laguillier-Morizot; Jean-Louis Beaudeux

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
141 KB
Volume
54
Category
Article
ISSN
1613-4125

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Numerous data are now available on the beneficial properties of the polyphenolic compound resveratrol including its anti‐inflammatory and antitumor effects. However, few studies have been performed with resveratrol in humans, and the results of these studies appear fragmentary and sometimes contradictory due to variations in conditions of administration, protocols and methods of assessment. This review article presents the results of recent studies investigating the pharmacokinetics, bioavailability, and toxicity of resveratrol in humans. Resveratrol is well absorbed, rapidly metabolized, mainly into sulfo and glucuronides conjugates which are eliminated in urine. Resveratrol seems to be well tolerated and no marked toxicity was reported. These data are important in the context of human efficacy studies, and they provide further support for the use of resveratrol as a pharmacological drug in human medicine.

📜 SIMILAR VOLUMES

Cloprednol bioavailability in humans
Cloprednol bioavailability in humans
✍ E. J. Mroszczak; R. Runkel; L. J. Strand; R. V. Tomlinson; A. Fratis; E. Segre 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB
Metabolism and bioavailability of trans-
Metabolism and bioavailability of trans-resveratrol
✍ Elisabeth Wenzel; Veronika Somoza 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB

Resveratrol (3,4',5-trihydroxy-trans-stilbene) is a polyphenolic compound accounting to the stilbene class. Most stilbenes in plants act as antifungal phytoalexins, compounds that are usually synthesized only in response to infection or injury. Resveratrol has been detected in trees, in a few flower

Bioavailability of propylthiouracil in h
Bioavailability of propylthiouracil in humans
✍ H. P. Ringhand; W. A. Ritschel; M. C. Meyer; A. B. Straughn; B. E. Cabana 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB
Pharmacokinetics and bioavailability of
Pharmacokinetics and bioavailability of pyridinol carbamate in humans
✍ Jean Sassard; Nicole Bernard; Jacques Legheand; Guy Cuisinaud; Jules Traeger 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB 👁 1 views

The pharmacokinetics of two pyridinol carbamate formulations were studied after a single oral administration in 10 healthy volunteers. An open one-compartment model described the evolution of plasma concentrations as a function of time. Pyridinol carbamate was rapidly absorbed (mean lag time from 0.