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Aromatic hydroxylation of .beta.-adrenergic antagonists. Formation of 4'- and 5'-hydroxy-1-(isopropylamino)-3-[2'-(allyloxy)phenoxy]-2-propanol from oxprenolol

✍ Scribed by Nelson, Wendel L.; Burke, Terrence R.


Book ID
121307627
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
1006 KB
Volume
22
Category
Article
ISSN
0022-2623

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The preparation and purification of 3–(4
✍ A. Bobik; E. A. Woodcock; C. I. Johnston; W. J. Funder 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 250 KB

## Abstract The preparation of an iodine‐125 labelled beta adrenergic ligand, 3–(4‐iodophenoxy)‐1‐isopropylamino‐2‐propanol, suitable for β‐adrenergic receptor membrane binding studies is described. Several preparations have been carried out with radiochemical yields of 20–30%. Specific activities