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Aromatic guanyl hydrazones: Synthesis, structural studies and in vitro activity against Trypanosoma cruzi

✍ Scribed by J.C. Messeder; L.W. Tinoco; J.D. Figueroa-Villar; E.M. Souza; R. Santa Rita; S.L. de Castro


Book ID
103983206
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
242 KB
Volume
5
Category
Article
ISSN
0960-894X

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## Abstract Research in recent years has demonstrated that the __Trypanosoma cruzi__ cysteine protease cruzain (TCC) is a valid chemotherapeutic target. Herein we describe a small library of aryl‐4‐oxothiazolylhydrazones that have been tested in assays against __T. cruzi__ cell cultures. The dockin