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Aromatic-backbone interactions in model α-helical peptides

✍ Scribed by Nicholas Y. Palermo; József Csontos; Michael C. Owen; Richard F. Murphy; Sándor Lovas

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
257 KB
Volume
28
Category
Article
ISSN
0192-8651

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✦ Synopsis

Abstract

The effects on helical stability of weak polar interactions between aromatic side‐chains and the peptide backbone were examined. α‐Helical model peptides, hexa‐Ala, with sequential Tyr replacement, were investigated computationally to obtain the geometries and energetics of the interactions. Geometries were obtained with the B3LYP/6‐31G* level of theory. Interaction energies were calculated using BHandHLYP/cc‐pVTZ and an improved method to correct for basis set superposition error when fragmentation caused steric clashes. Both i, i + 1 and i, i − 4 interactions were observed when Tyr was in position i = 5. The position of the aromatic residue in the amino acid sequence was crucial in facilitating aromatic‐backbone interactions. The distance between the center of the aromatic ring of Tyr and the individual interacting backbone atoms ranged from 3.65 to 5.50 Å. The interactions have energies of the same order as hydrogen bonds and, thus, could have a significant impact on the stability of the helix. © 2007 Wiley Periodicals, Inc. J Comput Chem, 2007

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