Two Helical Conformations from a Single Foldamer Backbone: “Split Personality” in Short α/β-Peptides

✍ Scribed by Ahlke Hayen; Margaret A. Schmitt; Felix N. Ngassa; Kathryn A. Thomasson; Samuel H. Gellman

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 188 KB
• Volume: 116
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200352125

✦ Synopsis

Oligomers that adopt predictable conformations ("foldamers") are subjects of increasing interest from the perspectives of both fundamental research and applications. [1] The study of unnatural oligomers that display secondary structures analogous to those of proteins or nucleic acids provides new insight on the parameters that influence the "foldability" of a backbone, e.g., the relationships between conformational stability and number of residues or residue flexibility. As the rules that govern shape are elucidated for new backbones, this