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Aromatic amino analogues of artemisinin: synthesis and in vivo antimalarial activity

✍ Scribed by Dharmarajan Sriram; Ruth Vandana Devakaram; Murugesan Dinakaran; Perumal Yogeeswari

Book ID
105770977
Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
595 KB
Volume
19
Category
Article
ISSN
1054-2523

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Two sets of tricyclic 1,2,4-trioxanes containing the ABC (10, 11) and ACD ring portions (21, 22, 32, 33, 37, and 38) of artemisinin (1) were synthesized by successive photo-oxygenation of appropriate enol-ether precursors to 1,2-dioxanes and inter-and intramolecular reaction with a carbonyl compound