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Arisostatins A induces apoptosis through the activation of caspase-3 and reactive oxygen species generation in AMC-HN-4 cells

✍ Scribed by Young-Ho Kim; Ho Cheol Shin; Dal Won Song; Sung-Hee Lee; Tamotsu Furumai; Jong-Wook Park; Taeg Kyu Kwon


Book ID
116286907
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
396 KB
Volume
309
Category
Article
ISSN
0006-291X

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## Abstract 3‐Hydroxyanthranilic acid (3HAA) is one of the tryptophan metabolites along the kynurenine pathway and induces apoptosis in T cells. We investigated the mechanism of 3HAA‐induced apoptosis in mouse thymocytes. The optimal concentration of 3HAA for apoptosis induction was 300–500 Β΅M. The