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ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?

✍ Scribed by Wu, J. N.; Roberts, C. W. M.


Book ID
118071521
Publisher
American Association for Cancer Research
Year
2012
Tongue
English
Weight
633 KB
Volume
3
Category
Article
ISSN
2159-8274

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## Abstract Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome‐wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylate