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Are trigger sequences essential in the folding of two-stranded α-helical coiled-coils?

✍ Scribed by Darin L. Lee; Pierre Lavigne; Robert S. Hodges

Book ID
115630727
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
321 KB
Volume
306
Category
Article
ISSN
0022-2836

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To determine when secondary structure forms as two chains coalesce to form an alpha-helical dimer, the folding rates of variants of the coiled coil region of GCN4 were compared. Residues at non-perturbing positions along the exterior length of the helices were substituted one at a time with alanine