Cyclin D2 and the CDK substrate p220NPAT
Cyclin D2 and the CDK substrate p220NPAT are required for self-renewal of human embryonic stem cells
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Klaus A. Becker; Prachi N. Ghule; Jane B. Lian; Janet L. Stein; Andre J. van Wij
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Article
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2010
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John Wiley and Sons
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English
⚖ 476 KB
## Abstract Self‐renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB‐dependent growth control. We investigated whether self‐renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220^NPAT^/HiNF‐P complex to activate __hi