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Are progenitor cells pre-programmed for sequential cell cycles not requiring cyclins D and E and activation of Cdk2?

✍ Scribed by D.-X. Xie; J. Yao; P. Zhang; X.-L. Li; Y.-D. Feng; J.-H. Wu; D.-D. Tao; J.-B. Hu; J.-P. Gong


Book ID
108677837
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
728 KB
Volume
41
Category
Article
ISSN
0960-7722

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Cyclin D2 and the CDK substrate p220NPAT
✍ Klaus A. Becker; Prachi N. Ghule; Jane B. Lian; Janet L. Stein; Andre J. van Wij 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 476 KB

## Abstract Self‐renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB‐dependent growth control. We investigated whether self‐renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220^NPAT^/HiNF‐P complex to activate __hi