Aqueous solutions containing amino acids and peptides. Part 20. Volumetric behavior of some terminally substituted amino acids and peptides at 298.15 K

✍ Scribed by Tracy E. Leslie; Terence H. Lilley

• Publisher: Wiley (John Wiley & Sons)
• Year: 1985
• Tongue: English
• Weight: 714 KB
• Volume: 24
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.360240409

✦ Synopsis

The densities at 298.15 K of aqueous solutions containing some terminally substituted amino acids and peptides containing the glycyl, L-and Dalanyl, I.-valyl, cleucyl, sarcosyl, and L-prolyl residues have been determined and standard state partial molar volumes and volumetric pairwise virial ,coefficients obtained. It is shown that the partial molar volumes can be represented using group volume contributions, but this approach is only approximate, and significant effects of N-terminal substitution and sequence dependence are observed. The volumetric virial coefficients for the amino acid amides have been expressed using a groupadditivity approach, and the results obtained indicate that the dominant contributions come from peptide group interactions with other peptide groups and with hydrophobic groups. There is also some evidence of both sequence and chiral effects on the volumetric virial coefficients for proline-containing dipeptides.