Determination of volatile amines in drug
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de Haan, P. E. ;de Jong, D. ;van den Berg, J. H. M. ;Kruse, C. G.
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Article
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1989
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John Wiley and Sons
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English
⚖ 355 KB
The determination of small, water soluble amines such as aziridine and 2-chloroethylamine, in drug substances at trace levels is described. After removal of the bulk of the drug substance by extraction or precipitation, derivatization with acid chlorides is performed. In a two-phase (water-organic s