Approaches to Handling Incomplete Data in Family-based Association Testing
โ Scribed by K. Van Steen; N. M. Laird; P. Markel; G. Molenberghs
- Book ID
- 111111326
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 105 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0003-4800
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract We provide a general purpose familyโbased testing strategy for associating disease phenotypes with haplotypes when phase may be ambiguous and parental genotype data may be missing. These tests for linkage and association can be used in candidate gene studies with tightly linked markers.
## Abstract In genetic association studies, the differences between the hazard functions for the individual genotypes are often timeโdependent. We address the nonโproportional hazards data by using the weighted logrank approach by Fleming and Harrington [1981]:__Commun StatโTheor M__ 10:763โ794. We
## Abstract The haplotypeโsharing correlation (HSC) method for association analysis using family data is revisited by introducing a permutation procedure for estimating regionโwise significance at each marker on a study segment. In simulation studies, the HSC method has a correct type 1 error rate