## Abstract Linkage and association analyses have played important roles in identifying susceptibility genes for complex diseases. Linkage tests and family‐based tests of association are often applied in the same data to help fine‐map disease loci or validate results. This paradigm increases effici
✦ LIBER ✦
Genomic screening and replication using the same data set in family-based association testing
✍ Scribed by Van Steen, Kristel; McQueen, Matthew B; Herbert, Alan; Raby, Benjamin; Lyon, Helen; DeMeo, Dawn L; Murphy, Amy; Su, Jessica; Datta, Soma; Rosenow, Carsten
- Book ID
- 109919178
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 238 KB
- Volume
- 37
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng1582
No coin nor oath required. For personal study only.
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## Abstract The haplotype‐sharing correlation (HSC) method for association analysis using family data is revisited by introducing a permutation procedure for estimating region‐wise significance at each marker on a study segment. In simulation studies, the HSC method has a correct type 1 error rate