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Applying Asymmetric Dihydroxylation to the Synthesis of Difluorinated Carbohydrate Analogues: A 1,1-Difluoro-1-deoxy-D-xylulose.

โœ Scribed by Liam R. Cox; Gareth A. DeBoos; Jeremy J. Fullbrook; Jonathan M. Percy; Neil Spencer


Book ID
101973693
Publisher
John Wiley and Sons
Year
2005
Weight
41 KB
Volume
36
Category
Article
ISSN
0931-7597

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1-Deoxy-D-xyluiose 5-phosphate is biotransformed to 2-C-methyl-D-erythritol 4-phosphate in a single step in the presence of NADPH by a new recombinant enzyme named l-deoxy-D-xylulose 5-phosphate reductoisomerase purified from Escherichia coli.