Applications of polymeric micelles with tumor targeted in chemotherapy
โ Scribed by Hui Ding, Xiaojun Wang, Song Zhang, Xinli Liu
- Book ID
- 118806758
- Publisher
- Springer Netherlands
- Year
- 2012
- Tongue
- English
- Weight
- 841 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1388-0764
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A plethora of formulation techniques have been reported in the literature for targeting drugs to specific sites. Polymeric micelles (PMs) can be targeted to tumor sites by passive as well as active mechanisms. Some inherent properties of PMs, including size in the nanorange, stability in plasma, lon
## Abstract To overcome multidrug resistance (MDR) existing in tumor chemotherapy, polymeric micelles encoded with folic acid on the micelle surface were prepared with the encapsulation of a potent MDR modulator, FG020326. The micelles were fabricated from diblock copolymers of poly(ethylene glycol